Personally, I have used it in drupal, wordpress and even now in blogger. I believed there are many people are using it as well; however, if you installed the recent version (v3.0.x), you may notices that the toolbar does not work well properly. Some how the toolbar icons are missing. The only icon you can see is the "?". It appeared to me that many people are experiencing the same issue: http://stackoverflow.com/questions/4607609/syntaxhighlighter-not-showing-toolbar. I spent an hour to try to solve it without luck. And even the demo page on it official web site also has the problem that can be seem here: http://alexgorbatchev.com/SyntaxHighlighter/manual/demo/toolbar.html.
Regardless of the problem with current version, if you still want to use syntaxhighligher, as I know of, v2.1.382 still work great and it is the version that I am using it on this post.
As a side note, to use syntaxhiglighter in blogger.com, the only thing need to modify is the template. Add the following code right before the end of head tag. However, if you are running on Dynamic view, you CANN'T modify the template in HTML form. For that, there's a great solution on this post http://www.alexconrad.org/2011/12/highlight-code-with-bloggers-dynamic.html
If you don't like the scripts from Alex Gorbatchev for some reasons. There are other solutions you may find interested and may be easier to implement.